In vitro hypoxia exposure can also mediate larger scale genomic instability by increasing fragile site induction, gene amplification and cellular DNA content [ 7- 9].
This C-terminal region could serve to initiate the formation of the coiled-coil heterodimer, which was proposed to serve as a flexible hinge and mediate large-scale changes within the Mediator complex.
Since, repetitive elements are numerous in the human genome; consequently SSA could mediate large-scale rearrangements that cause deletions of sequences located between the repeats.
In this context, apoptosis-inducing factor (AIF) and endonuclease G (Endo G) relocated to the nucleus and mediate large-scale DNA fragmentation.
DNMT3B appear to mediate large-scale methylation patterns in hESCs; its deficiency in the cells alters the timing of their neuronal differentiation and maturation.
Indeed, repetitive elements are numerous in yeast genomes, consequently SSA could mediate large-scale rearrangements that cause deletions of sequences located between the repeats.
Beyond molecular-scale changes, active TE transposition can mediate large-scale chromosomal rearrangements leading to karyotypic variation, which is a factor in the formation of reproductive barriers and speciation (Rieseberg 2001; Levin 2002).
The authors' team first introduced gap-junctions into the cortical model in the paper Gap-junction mediate large-scale Turing structures in a mean-field cortex driven by subcortical noise[ 44].
Similarly, our own modelling of the hindgut demonstrates that even comparatively modest changes in localised intercellular adhesion are able to mediate large-scale changes in organ shape and curvature.
This latter step may provide time for epigenetic events to mediate large-scale transcriptome re-organisation; consistent with this, we uncover simultaneous downregulation of major chromatin modifiers as the neural programme is established.
Alternatively, endonuclease G (EndoG) can translocate to the nucleus, where it is capable of mediating large-scale DNA fragmentation independent of caspase activity.
