Sentence examples for mediate its role from inspiring English sources

Taken together, these results identify a cohort of STAT3 targets that may mediate its role in oncogenesis.

The clathrin adaptor Dab2 appears to be involved in trafficking integrin receptors to mediate its role in migration [50].

The second hypothesis would be that CDK11p58 might also mediate its role via its direct interaction with Plk4.

Thus, some activities, although only transiently associated with shelterin, may be important to mediate its role in telomere function.

KLK13 could mediate its role either by generating or activating breast cancer inhibitory factor(s) or by terminating the action of unfavourable factor(s).

Searching for putative Sall2 targets that could mediate its role in apoptosis, we identified proapoptotic NOXA/PMAIP1 phorbol-12-myristate-13-acetate-induced phorbol-12-myristate-13-acetate-induced phorbol-12-myristate-13-acetate-induced phorbol-12-myristate-13-acetate-induced phorbol-12-myristate-13-acetate-induced phorbol-12-myristate-13-acetate-induced

However, it is not clear how OAZ mediates its role in cell differentiation at present.

Low levels and local distribution of mitochondrial ROS mediates its role as a second messenger and are required for cellular survival and adaptation, whereas high levels of ROS mediates its role as a death signal.

TFAP2α mediates its role as a differentiation associated transcription factor through positive regulation of p21 thereby negatively regulating the cell cycle.

P21 (named CDKN1A or WAF1) is an important intermediate through which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage; its overexpression plays a critical role in cell cycle arrest [ 21, 22].

There is evidence that CBP mediates its role in brain plasticity via histone-acetylation-dependent gene expression (Vecsey et al, 2007), and one study provided evidence that the role of CBP/KAT3A during learning critically depends on its ability to induce the expression of nuclear receptor 4a1 (Nr4a1; McNulty et al, 2012).