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Alternatively, L. pneumophila can mediate its own release without lysing the host cell [11].
Motivated by our previous findings that Stx can mediate its own uptake and affect signaling, we set out to investigate if Stx, although binding to a glycolipid, was able to increase the formation of endocytic clathrin coat structures at the plasma membrane and if such increase in clathrin coats might be mediated by signaling through the Syk kinase.
Spry2 binds protein phosphatases (SHP2; PP2A) that can mediate its own dephosphorylation as well as that of other phosphoproteins.
Tn 916 has been shown to have the ability to transpose intracellularly and to mediate its own intercellular transfer via conjugation [ 14].
To mediate its own secretion, an autotransporter contains three functional domains: an N-terminal signal sequence, an extracellular passenger domain, and a C-terminal β-barrel domain.
If this property of pPDL2 is taken together with its ability to mediate its own mobilization, designating pPDL2 as an IME appears to be logical.
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The N-terminal C2 lipid-binding domain of Nedd4 has been shown to mediate Ca2+-dependent phospholipid binding and membrane association [ 21], in addition to mediating its own protein protein interactions that serve to localize it to apical rafts [ 22].
EEA1 does not contain any identifiable UIMs, but it might have a cryptic ubiquitin binding site that mediates its own ubiquitination.
The excised intervening sequence of the Tetrahymena ribosomal RNA precursor mediates its own covalent cyclization in the absence of any protein.
Several reports are corroborating the fact that high level of IFN-γ produced by the Th1 population mediates its own apoptosis by up-regulating both Fas and Fas-L expression [25], [26], [27], [28].
It is known that even in yeast Tom40 mediates the import of new molecules of Tom40 into mitochondria [67] and it is tempting to speculate that the Giardia Tom40 is capable of mediating its own import and membrane insertion, given the highly simplified nature of the TOM complex in mitosomes.
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