Sentence examples for mediate its localization from inspiring English sources

The di-leucine motifs in both N- and C-terminus mediate its localization to late endosome and lysosome (Venkatachalam et al., 2015; Vergarajauregui and Puertollano, 2006).

MTMR4 possesses several protein protein and protein lipid interaction domains including the FYVE domain, shown to mediate its localization to endosomes through its interaction with PtdIns3 P and PtdIns 3,5) P2 [ 14] and is the only family member possessing a PY motif.

We found that MULAN is a mitochondrial protein – two transmembrane domains mediate its localization to the organelle's outer membrane.

In Drosophila, the N-terminal region of the DEAD-box protein Abstrakt mediates its localization into nucleus.

Here I sought to determine by analyzing the activity of contiguous fragments which part of Tud mediates its localization in the nuage and pole plasm during oogenesis and to identify the functional part of Tud.

Intramolecular disulfide formation in the small molecular chaperone, DnaJb5 and the class II histone deacetylase, HDAC4 results in sequential dissociation of the DnaJb5-HDAC4 complex, unmasking of the HDCA4 NES to mediate its cytoplasmic localization and derepression of target genes involved in hypertrophy.

Ft does not bind to D itself, indicating that there must be one or more proteins that bind to Ft and mediate its regulation of D localization at the membrane.

Sumoylation of lipin-1α, in addition to mediating its nuclear localization, also appears to be required for its transcriptional coactivator activity toward PGC-1α and MEF2 in neuronal cells (see paragraph below).

A recent study [ 28] suggested that the mechanism by which normal HFE protein regulates hepcidin expression is by binding intracellular ALK3 and mediating its cell surface localization.

By using genome-wide binding studies, we find that Abd-B mediates its effects on integrin localization by directly controlling at multiple levels the signaling activity of the Sev ligand Boss via its direct targets src42A and sec63, two genes involved in protein trafficking and recycling.

While delineating how PHB promotes the proliferation of BC cells, we hypothesized that it is through mitochondrial localization that PHB mediates its effects.