Sentence examples for mediate its interaction from inspiring English sources

If Sir2 is not sumoylated, it is presumable that some sumoylated proteins may mediate its interaction with other proteins such as Esc2 and regulate its activity.

Domain I of NS5A, was sufficient to mediate its interaction with NS4B.

The Derbyshire lab has previously identified that the C-terminal domain of PfHsp70-1 mediateitse interactiontion with PI3P, which could play an important role in parasite survival.

We transfected Agt5 −/− MEF cells with wild-type p62 or a LIR deletion mutant, which was reported to mediate its interaction with LC3 for autophagic degradation, and found that the protein level of p62 or its LIR deletion mutant were significantly reduced when parkin is expressed in these cells (Fig. 3C).

The macro domain alone of LRP16 is enough to mediate its interaction with both p65 and AR.

Conversely, we find that all three mammalian HP1 isoforms, HP1α, HP1β and HP1γ bind to ADNP and mediate its interaction with H3K9me3 in vitro.

The BIR domains of cIAP1 also mediate its interactions with other proteins such as Traf2, Smac, and RIP1.

It is worthwhile to consider the interactions among the three major domains because, by varying its own conformation through such interactions, Hsp90 may mediate its interactions with different co-chaperones and clients and fulfil its extremely diverse biological functions.

FAF1 is a 74-kDa protein with an N-terminal domain that mediates its interaction with Fas, the Fas-interacting domain (FID), and a functional ubiquitin-like C-terminal domain that is required for its pro-apoptotic activity.

The lysosomal localization of AGA is dependent on a conformational determinant that mediates its interaction with the phosphotransferase that generates the M6P signal, a prerequisite for the lysosomal targeting of AGA21.

The SH3 domain of CAS mediates its interaction with several proteins involved in signaling pathways such as focal adhesion kinase (FAK), tyrosine phosphatases PTP1B and PTP-PEST, and the guanine nucleotide exchange factor C3G.