Sentence examples for mediate its downstream from inspiring English sources

We next investigated whether the lapatinib-activated NF-κB can mediate its downstream gene expressions.

In a previous publication [ 2], we discussed two possible mechanisms via which Rheb might mediate its downstream effects.

c-Myc has been found to be amplified in more than half of refractory prostate cancers (Bernard et al, 2003; Clegg et al, 2011) and has been identified as one of the key players in cell potency (Takahashi et al, 2007), but the factors which mediate its downstream effects in late-stage prostate cancer are still not well understood.

TNF-α mediates its downstream effects by transducing signals to different effectors, including IKK, JNK and caspases [10].

Since IL-17A mediates its downstream effects by stimulating the release of multiple other cytokines [ 9], we examined which factors in the bone and lung may be influenced by anti-IL-17A antibody treatment.

These data indicate an epistatic relationship where Rnd1 acts downstream of Unc5B to mediate its cell deadhesion activity.

Evidence for a role of S6K1 in regulation of mouse lifespan has been presented recently [13], suggesting that the aging-modulating effect of mTOR is mediated through its downstream effector S6K1.

Further, RhoA effects are mediated via its downstream effector ROCK.

Further experiments indicate that the proautophagic capacity of miR-182 is partially mediated by its downstream targets Bcl-2 and p21 [ 91].

Interestingly, these roles of ARF6 are mediated via its downstream effector phospholipase D (PLD) [ 59, 92], an enzyme which as well takes part in the later maturation steps of autophagy [ 25].

Much more work is needed to further define the roles of ACC and the downstream elements mediating its perception and signal transduction.