Sentence examples for mediate its degradation from inspiring English sources
Thus, in PHKs, MDM2 is expected to ubiquitinate p53 and mediate its degradation by nuclear and cytoplasmatic proteasomes.
P25 VSRS is known to interfere with the AGO1, the central component of the RISC complex, and mediate its degradation through the proteosomal pathway [ 64].
57 In addition, TNF-α upregulates the expression of suppressor of cytokine signaling (SOCS) proteins, which bind to IRS-1 to mediate its degradation.
Given the negative correlation between Sp1 and MDM2 protein levels after nutlin treatment, we hypothesized that, on its release from p53, MDM2 stabilized by nutlin could bind to Sp1 and mediate its degradation.
As an E3 ubiquitin ligase, Mdm2 binds to p53 to mediate its degradation; in addition, Mdm2 is overexpressed in many human tumors to antagonize p53 function that plays an important role in cancer initiation and development.
E6 has been reported to bind to hScrib and to mediate its degradation, thus eliminating its control on cell cycle progression [ 83]. hScrib is primarily found associated with epithelial tight junctions, and loss of this protein leads to the inability of cells to adhere to the ECM.
Studies employing a co-infection model with HSV-1 and Sendai virus (SeV) found that ICP0 inhibited IRF3 nuclear translocation and mediated its degradation [35], [36].
This is because trabectedin is eliminated through hepatic metabolism and CYP3A4 is the principal responsible enzyme mediating its degradation [ 7].
Through the ubiquitin ligase activity of MID1 this complex acts as a negative regulator of protein phosphatase 2A (PP2A) by mediating its degradation [ 15].
The E3 ubiquitin ligase CHIP (carboxyl terminus of the hsp70-interacting protein) ubiquitinates phosphorylated tau and mediates its degradation (16, 17, 204).
Mechanistically, Smurf1 associates with the transcription factor Runx2 and mediates its degradation in ubiquitin- and proteasome-dependent manner, resulting in inhibition of osteoblast differentiation and bone formation.
