Sentence examples for mediate its actions from inspiring English sources

We discuss recent advances in understanding the molecular pharmacology of xenon and we highlight specific pharmacological targets that may mediate its actions as an anesthetic and neuroprotectant.

Currently available data suggests that Met may mediate its actions by interaction with other nuclear proteins such as Taiman (see Jindra et al. (2013) Annu Rev Entomol for a comprehensive review).

Elevated IL-5, which uses the neural plasticity-related RAS-ERK pathway to mediate its actions in the CNS, could be one of the factors underlying depression-related changes in CNS plasticity.

On the other hand, Sprouty may mediate its actions in part by increasing active contents of such phosphatases as protein tyrosine phosphatase 1B (PTP1B) and phosphatase and tensin homolog (PTEN).

Elevated levels of IL-5, which uses the neural plasticity-related RAS GTPase-extracellular signal-regulated kinase (Ras-ERK) pathway to mediate its actions in the central nervous system (CNS), could be one of the factors underlying the depression-related changes in CNS plasticity.

PGE2 is reported to mediate its action by interacting with four subtypes of PGE receptors, the EP1, EP2, EP3 and EP4 receptors [50], but may also bind to the prostaglandin F (FP) receptor with an affinity that is only 10 30 fold lower than that of PGF2α [51].

Furthermore, the At-FEI1 and At-FEI2 LRR-RLKs have been speculated to bind to At-FLA4 and mediate its action (Xu et al., 2008).

BDNF is confirmed to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB) [ 42].

Since the two studies were conducted in animals in which microglia were present to surround neurons, it is therefore possible that testosterone has an anti-inflammatory role to mediate its action on PSD-95 through monitoring the neighboring microglia [ 46].

We hypothesized that Rac1 might mediate its action at inhibitory synapses by activating PAK, which is supported by our observation that an SH3-domain mutant of βPIX (which can no longer couple to PAK) is unable to rescue the effects of βPIX RNAi on GABAAR clusters.

It mediates its actions via the CCK1 and CCK2 receptors.