The release of hormones and neurotransmitters by Ca2+-triggered exocytosis mediates a wide variety of biological processes, including for instance interneuronal communication and the control of diverse cardiovascular functions.
In some types of nerves the synapses do not possess receptors, in which case interneuronal communication is achieved by electrical transmission.
Because nerve cells synthesize the neurotransmitters necessary for interneuronal communication, it is not surprising that Alzheimer's disease is associated with diminished levels of neurotransmitters, including acetylcholine, norepinephrine, and serotonin, as well as modulatory neuropeptide molecules that transmit signals between nerve cells.
Microdialysis provides a direct approach to monitor changes in interneuronal communication by monitoring the fluctuation of local, extracellular concentrations of potential neurotransmitters/neuromodulators.
Our results indicate that information transmission delays can either promote or impair synchrony among neurons and can thus effectively supplement other mechanisms of synchronization [49], [50] on scale-free networks, which arguably constitutes an important ingredient of interneuronal communication.
Glutamate receptors were initially demonstrated to play important roles in excitatory neurotransmission in the brain and interneuronal communication[ 16].
DOI: http://dx.doi.org/10.7554/eLife.02391.002 Neurotransmitter release is crucial for interneuronal communication and is exquisitely regulated by a sophisticated protein machinery (Sudhof, 2013).
GRIK1 is a kainite receptor used for interneuronal communication and uses microtubules to get transported to the surface of dendrites [ 59, 60].
Second, we define its component features in the wild‐type (WT) SCN and, finally we determine how these features are affected in SCN slices from Cry‐null mutant animals in which the molecular/cellular feedback loop is compromised, and in VPAC2‐null animals that lack VIP‐mediated interneuronal communication.
In addition to metabolic functions, such metabolic products mediate crucial interneuronal communications in the brain.
