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This notion is supported by demonstration that astrocytic gap junctions mediate intercellular spread of sodium during electrical stimulation of hippocampal slices to stimulate glutamatergic pathways (Langer et al., 2012).
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Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells.
aGPCRs have large alternatively spliced extracellular regions (ECRs) that likely mediate intercellular signaling; however, the precise roles of ECRs remain unclear.
Dear Editor, Exosomes are cup-shaped small (30 150 nm) extracellular vesicles with the structure of lipid bilayer membrane (Tkach and Thery, 2016) containing proteins, mRNAs and microRNAs that mediate intercellular communication (Valadi et al., 2007).
MPs mediate intercellular communication (Zhao et al., 2016; Tian et al., 2015; Budnik et al., 2016; Zappulli et al., 2016), resulting in secondary injures such as systemic coagulopathy and inflammation after TBI (Zhao et al., 2016; Tian et al., 2015).
Furthermore, exosomes carrying miRNA are believed to mediate intercellular signalling between tumour cells and bystander cells (Melo et al. 2016; Yang et al. 2011; Umezu et al. 2013; Sánchez et al. 2015).
Cell surface proteins mediate intercellular recognition and signal transduction.
Very little is known about the intercellular spread of lymphotropic gamma-herpesviruses.
Intercellular spread begins between 3 and 5 hours post infection [13] [15].
So while intercellular spread must involve binding, this seems unlikely to be rate-limiting.
For example, microvesicles may mediate intercellular communication by transporting bioactive lipids, mRNA, or proteins between cells.
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