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Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells.
Dear Editor, Exosomes are cup-shaped small (30 150 nm) extracellular vesicles with the structure of lipid bilayer membrane (Tkach and Thery, 2016) containing proteins, mRNAs and microRNAs that mediate intercellular communication (Valadi et al., 2007).
MPs mediate intercellular communication (Zhao et al., 2016; Tian et al., 2015; Budnik et al., 2016; Zappulli et al., 2016), resulting in secondary injures such as systemic coagulopathy and inflammation after TBI (Zhao et al., 2016; Tian et al., 2015).
For example, microvesicles may mediate intercellular communication by transporting bioactive lipids, mRNA, or proteins between cells.
Ephrins are cell-surface signaling molecules that bind in trans to Eph receptor tyrosine kinases to mediate intercellular communication.
Immunological synapses mediate intercellular communication between T cells and target cells, both in vitro and in vivo.
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Here, Prof. Zhang also report that secreted miRNAs can serve as novel signaling molecules mediating intercellular communication.
Open image in new window Figure 2 A schematic illustration of MPs-mediated intercellular communication in TBI.
Gap junction-mediated intercellular communication (GJIC) is critical for maintaining integral cellular processes including differentiation and growth control.
Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix (ECM) and maintenance of renal tissue architecture.
The in vitro studies also showed that miRNA expression profiles in conditioned medium were different from those in cells, and those secreted miRNAs may represent a class of signaling molecules in mediating intercellular communication [17], although the mechanisms control microRNA packaging and secretion are largely unknown.
More suggestions(15)
mediate intercellular recognition
mediate direct communication
mediate intercellular signaling
mediate allosteric communication
mediate resonant communication
mediate interneuronal communication
mediate intercellular information
mediate sexual communication
mediate intercellular adhesion
mediate intercellular gene
mediate normal communication
mediate rapid communication
mediate intercellular membrane
mediate bacterial communication
mediate intercellular competition
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