Sentence examples for mediate inflammatory effects from inspiring English sources

Receptors of IFN-γ inducible chemokines are members of the seven-transmembrane-spanning, G-protein-coupled receptor family, and are thought to mediate inflammatory effects of chemoattractants within RA synovial tissue [ 6, 20].

Importantly, though we interpret these regions as mediating inflammatory effects on blood pressure, mediation analyses cannot definitively determine causality i.e. it is also plausible that changes in blood pressure mediate inflammation associated changes in dACC activity (perhaps representing altered afferent traffic from baroreceptors reflected in HRV changes).

In addition to its pro-pruritic effect, several studies acknowledge a role for the H1R on immune cells in mediating inflammatory effects of allergic skin diseases with antagonism of the H1R by several drugs demonstrating anti-inflammatory properties in different experimental models of AD [15 19].

This suggests a direct role in mediating inflammatory effects on blood pressure via modulation of baroreflex sensitivity.

Finally, these pro-inflammatory cytokines (IL-6 and TNF-α) mediate distant inflammatory effects, including activation of CRP and SAA-2 [ 41].

These mediators could then travel to the heart and blood vessels, where they may mediate downstream inflammatory effects (Brook et al. 2010).

Realization of the important role played by UA as a signaling molecule mediating the inflammatory effects of hyperuricemia in adipocytes and leukocytes, as well as in signaling to cancer cells (Figure 3) has emphasized the relevance of managing UA therapeutically which could significantly improve treatment strategies for cancer that is associated with hyperuricemic disorders.

Th1 cells themselves produce IFN-γ, which perpetuates the upregulation of CXCR3 ligands and mediates downstream inflammatory effects responsible for lesion formation and persistence.

These results highlight important roles of spondin 2 in mediating cellular inflammatory effects [ 167], and implicate TH in diverse functions that influence liver cancer progression.

This finding supports our hypothesis that anti-AT1R and anti-ETAR Aabs mediate inflammatory and profibrotic effects via an activation of their respective receptor.

In our study we shown an up-regulation of PPAR-γ transcripts and thus Sc could also mediate anti-inflammatory effects through activation of PPAR-γ.