Sentence examples for mediate induction of from inspiring English sources

This combination of properties suggests that the DMF may activate the Nrf2 transcriptional pathway known to mediate induction of phase 2 genes by SH-reactive electrophiles and play a major role in cell and tissue defense against oxidative stress.

These characteristics imply that fumarates may activate the Nrf2 transcriptional pathway which is known to mediate induction of phase 2 genes by SH-reactive electrophiles and to play a major role in cell and tissue defense against oxidative stress [29].

p75NTR stimulates calpain activation through its Chopper cell death domain, [11] and mediates NGF-induced inhibition of GSK-3β [12]; in addition, it can mediate induction of cell death through the activation of JNK [13].

Direct Chlamydia-endothelial cell interactions are known to mediate induction of VEGF [ 37].

These data suggest that elevated ROS may be mediate induction of c-Jun and AP-1 activity in response to reduced fibroblast spreading/mechanical force.

However, the factors that mediate induction of TNFR2 in injured TECs and its contribution to the process of rejection are incompletely understood.

Additionally, we showed that PD-1 was necessary for DC-mediated induction of regulatory T cells.

We also discuss our current understanding of the molecular mechanism behind Xist RNA-mediated induction of the repressive epigenetic landscape at the Xi.

PALS1 knockdown led to a significant decrease in TCR-mediated induction of the activation markers CD69 and CD25 on cell surface (Figure 2A, B).

We found that Nod2 mediates induction of pro-IL-1β, TNF-α, IL-6, IFN-α and CXCL10 in response to B. burgdorferi in BMDM in vitro.

Western blot analysis indicated that heat shock mediated induction of endogenous Hsp90 expression was not inhibited in GFP positive tadpoles (Fig. 4C).