Sentence examples for mediate host defense from inspiring English sources

We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans.

An immunologist whose research has contributed to the understanding of the precise mechanisms of how white blood cells respond to chemical signals to mediate host defense or tissue damage, Snyderman accepted his first faculty appointment at Duke in 1972.

Another mechanism by which SP-A can mediate host defense is via direct modulation of alveolar macrophage function.

They are target cells for infection and they secrete cytokines and chemokines upon infection which mediate host defense and potentially contribute to the inflammation of the bronchial mucosa.

This new appreciation of TRM that reside in epithelial tissues and mediate host defense has been studied most extensively in skin: adult human skin contains large numbers of functional TRM that express skin specific markers.

Therefore, these cells may directly mediate host defense even before foreign antigen-specific T cells have differentiated.

Classically activated macrophages (M1) exhibit a pro-inflammatory role, mediating host defense against microorganisms or tumor cells; whereas alternatively activated macrophages (M2) perform a range of physiological processes, including inflammation, wound repair and tissue remodeling.

Of note, vaccination with facultatively intracellular pathogens, like B. henselae, could also depend on effective T-cell memory for mediating host defense and production of specific antibodies.

It has now become clear that the TLR-dependent innate immune response is essential in mediating host defense to infection and to infection-related inflammation and tissue remodeling [7], [8].

SP-A mediates host defense via direct interactions between the carbohydrate recognition domain of SP-A and microbial ligands, which results in the opsonization and phagocytosis of pathogenic microorganisms by alveolar macrophages, and indirectly via modulation of the host immune response [7] [9].

Symbiotic microbes may represent a particularly promising source because microbial symbioses are widespread [e.g., [22]], largely unexplored for natural products [cf. [5]; but see [16]], and often involve the exchange of small molecules between symbionts and hosts [cf. [16]], including compounds mediating host defense [e.g., [11], [17] [19]].