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Likewise, formin proteins could mediate growth of long filaments from focal adhesions between lamellipodium and lamellum [70] or from the leading edge [71].
For example, in prostate, breast and pancreatic carcinoma cells, JNK, or the upstream activator of both kinases, MKK4, has been demonstrated to mediate growth of cells in vitro, and as xenografts in vivo [33], [34].
These studies suggest that IL-4 induced signal transduction does not seem to mediate growth of tumour cells.
We hypothesised that chemoresistant cancer cells and CSCs generate soluble factors that could mediate growth of otherwise sensitive tumour cells and mediate resistance to chemotherapy.
Notably, neither ArsC nor GstB expression could mediate growth of the glutathione null strain WP758 (DHB4 Δ gshA) in media containing more than 0.1 mM sodium arsenate (data not shown).
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Activation of vascular endothelial growth factor receptor-2 (VEGFR-2 also called FLK-1/KDR) plays a pivotal role in mediating growth of blood vessels, angiogenesis [1].
However, imaginal tissues are not spared upon starvation, arguing against an important function of ALK in mediating growth of imaginal discs under NR conditions.
This maxi-EBV plasmid is fully competent to give rise to progeny virus when propagated in appropriate cells or can directly mediate growth transformation of human B cells upon DNA transfection [16], [17].
FABP7 was also shown to induce mammary differentiation and to mediate growth inhibition of breast cancer cells [ 19, 20].
Since previous reports have shown that SSTR4 agonists mediate growth inhibition of neuroendocrine cells (Patel, 1999; Weckbecker et al, 2003), we next examined the effect of SSTR4 on MPM cell migration, invasion and colony formation.
We next asked whether BMP4 and Megf8 functionally interact to mediate growth and guidance of TG axons.
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