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They have also been shown to mediate germ cell migration in zebrafish, chickens, and mammals [12] [17].
It has been reported that transmembrane protein molecules present at the junctional complex located in the seminiferous tubules transduce signals, maintain cell polarity, and mediate germ cell migration [24].
Tp53 (p53) has been reported to mediate germ cell apoptosis and regulate oocyte survival through meiosis.
This implies that Vas must be catalytically active to mediate germ cell specification.
Alternatively, it was possible that daf-16 regulates kri-1 to mediate germ cell death; however, neither kri-1 transcript nor protein levels were significantly affected in daf-16 lf) daf-16 lf
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This study provides conclusive evidence that the arginine of the highly conserved E/N/DRY motif is critical for Tre1 GPCR-mediated germ cell migration within the context of a developing organism.
To further refine the molecular basis for this phenotype, we assayed the effects of single amino acid substitutions in transgenic animals and determined that the arginine within the evolutionarily conserved E/N/DRY motif is critical for receptor function in mediating germ cell migration within an intact developing embryo.
Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and mineralisation, and mediating germ cell development.
These observations raise questions about the role of conserved and nonconserved elements in mediating germ cell-specific expression.
Our data suggest that l-Trp metabolites induce a SKN-1-mediated detoxification response that might mediate rescue of germ cell production in OP50-fed nhr-114 mutants, but also that l-Trp supplementation alone does not recapitulate the benefits of HT115 feeding for longevity.
An interesting potential link between Prdm14 function and Prdm16 is that Prdm14 mediates the acquisition of germ cell pluripotency in part by upregulating Sox2 [54].
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