Sentence examples for mediate gene induction from inspiring English sources

The ability of DevRC to mediate gene induction was confirmed at the protein level.

IL-1 is also involved in IFN-α-mediated antiviral gene induction in human hepatoma cells [14].

One of the molecules mediating this gene induction is a regulatory protein called nuclear factor-κB, which activates many innate immune genes.

To test whether PPAR alpha mediates peroxisomal gene induction by DHEA-S in intact animals, DHEA-S has been administered to mice lacking a functional PPAR alpha gene.

It has been reported that Hes1, which is expressed in the spinous layers, mediates spinous gene induction but not repression of basal layer genes, raising the possibility of involvement of other Hes/Hey family genes [ 21 ].

However, we do not find a tight link between IFN-β-mediated xaf1 gene induction and decrease in average methylation within xaf1 promoter region in HeLa and SK-N-AS cells occurring at later time points.

The proinflammatory function of NF-κB in renal cells is also subject to regulation by the p50/p50 homodimer, a κB-specific repressor that is induced during experimental renal injury and serves as a feedback repressor of NF-κB-mediated inflammatory gene induction [ 90, 91].

Inhibitor panel testing identified PI3K inhibitor LY294002 as a novel inducing agent and revealed potential roles for NFκB and VEGFR/PDGFR/Raf kinases in HS-mediated γ-globin gene induction.

Hes1 is expressed in spinous layers and mediates spinous cell gene induction and thus terminal differentiation of epidermal keratinocytes [32].

Clearly the mechanism by which PPAR agonists dilate vessels acutely must be mediated independently of gene induction as the response is seen within minutes of adding the drug.

Clearly with such acute exposure, and as platelets have no nucleus, effects of PPARβ/δ agonists on platelet function must also be mediated independently of gene induction and the nucleus.