Sentence examples for mediate gene down-regulation from inspiring English sources
miRNAs are small noncoding RNA molecules on average 22 nucleotides in length that regulate numerous biological processes including cancer pathogenesis and mediate gene down-regulation by targeting mRNAs to induce RNA degradation and/or interfering with translation.
Therefore Oct-4-mediated p21 gene down-regulation may be a key mechanism for the stimulation of cell-cycle progression of the ICM.
Here we report an efficient and handy alternative for E. histolytica gene down-regulation mediated by bacterial double-stranded RNA (dsRNA) targeting parasite genes.
Using mostly band shift and transient transfections assays several groups have suggested that TR interacts with an inhibitory element immediately downstream of the transcription start site, and that this interaction is important for TSHβ gene down-regulation mediated by T3 [17][43], [43], [43].
A positive value indicates gene up-regulation and a negative value indicates gene down-regulation.
Remarkable luciferase gene down-regulations have confirmed their outstanding RNAi effects.
A positive value indicated gene up-regulation while a negative value indicated gene down regulation.
The role of FORCA may be to limit the amplitude of FORC gene induction and/or to mediate the down-regulation of FORCs after an early peak of their transcript levels is reached.
The elucidation of the mechanisms that could mediate the down-regulation of Ip awaits further studies.
Altogether, our results indicate that Mxi1 mediates the down-regulation of cyclin B1 gene expression in malignant gliomas suggesting that this gene is a functional target of the tumour suppressor activity of Mxi1.
Comparing the two high-exposure groups CDH and MDH, in addition to the mentioned effect on the proteasome complex, the main difference between them seems to be that chemically dispersed oil specifically affected nucleosome assembly and DNA methylation by up-regulation of transcripts involved in these mechanisms, while mechanically dispersed oil mediated a down-regulation of the same gene sets.
