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Delivering genes to mediate functions of cells is a crucial technology for both basic science and clinical applications.
Indeed, multiple signal transduction pathways have been shown to mediate functions of Eph receptors, including the Src family kinases (31- 33), Rho family GTPase (34), cGMP-dependent protein kinase (PKG) (33, 35), and myosin light chain kinase (MLCK) (33).
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Its functions are relatively unknown, except that it is coexpressed with CXCR3-A at very low levels and that CXCL10 does not bind to this isoform and only mediates functions of CXCL11 [ 47].
This multixenobiotic resistance mediating function of the protein contrasts to mammalian ABCB4, which is a specialized translocator of phosphatidylcholine (PC) into bile that transports cytotoxic drugs only at low rates and does not confer multixenobiotic resistance [ 8].
Nonetheless these findings lend support to a model in which a non-classical MAP Kinase pathway mediated by TAK1/p38/JNK or TAK1/NLK mediate some functions of the endoderm.
These studies reaffirm and extend the importance of AT1 receptors to mediate physiological functions of the renin-angiotensin system.
Chemokines are produced by macrophages, lymphocytes, neutrophils and dendritic cells and mediate various functions of these cells, including recruitment of other cells [47], [48].
Different forms of ERs mediate distinct functions of E2.
However, the mechanisms that mediate the functions of TRPM7 in vertebrate organogenesis are poorly understood.
These genes mediate molecular functions of nuclear DNA binding, transcription-factor activity and oxidoreductase activity.
Recent studies have identified several downstream pathways that mediate the functions of these receptors.
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