Sentence examples for mediate down from inspiring English sources

We focused our present study to determine the regulation of cell cycle progression in the glioma cells when co-cultured with hUCBSC and attempted to determine the potential of hUCBSC to mediate down regulation of cyclin D1, thereby reducing the cell cycle progression by arresting them at G0-G1 phase.

It is likely that C. lentis secretes the fasciclin homolog ClCE8 during conidium and appressorium adhesion on the plant surface, though it might also mediate down-stream infection related to fungal development.

When HIF-1α and HIF-2α were inhibited simultaneously using RNA interference there was no effect on the DICER mRNA repression, suggesting a lack of HIF-1α or HIF-2α mediated down regulation of DICER mRNA levels after exposure to hypoxia.

NK cells have been shown to exert antiviral effects both via perforin/granzyme-mediated cytotoxicity and via IFN γ-mediated down-regulation of HCV replication in in vitro models.

The signaling mechanisms mediating down-regulation of PPAR-γ in response to these cues are not well understood.

In the cell YopM mediates down-regulation of inflammatory responses.

Overall, these data also suggest that systemic/serum SK1/S1P mediates down-regulation of Brms1 via S1PR2 signalling in cancer cells.

In the present study, hR1 and Hex-hR1 were likewise very effective at mediating down-regulation of IGF-1R in RCC.

Overall, the data demonstrate that BPA induces PPARγ, which mediates down-regulation of FSH-stimulated IGF-1, SF-1, GATA4, aromatase, and E2 in human granulosa cells.

These data are in line with reports on insulin mediated down-regulation of TAG-enriched VLDL1 particles without affecting the (lipid-poor) VLDL2 secretion [ 16, 23].

This could be linked to the observation that the hexavalent form of hR1 is more effective at mediating down-regulation of IGF-1R than the parental hR1.