The activation function 2 (AF2) site is a coregulator binding site in the ligand-binding domain (LBD) of ERα that recruits a variety of coactivator proteins and mediates diverse functions of ERα.
ERK1/2 responds to stimulation by a variety of different hormones, growth factors, and insulin [ 18, 25- 27] and mediates diverse functions including modulation of proliferation, differentiation, apoptosis, migration, and cell adhesion [ 28- 31].
Hyperthermia may trigger immune responses that inhibit the metastasis of graft tumors [ 30]. "Cluster of differentiation 44" (CD44) is a cell surface adhesion molecule that recognizes hyaluronate and mediates diverse functions, such as cell-cell and cell-matrix adhesion, lymphocyte homing, and T-cell adhesion and activation.
Neurons that release serotonin as a neurotransmitter project to most regions of the central and peripheral nervous system and mediate diverse neural functions.
Five receptor subtypes (D1-5) mediverseiverse dopamine functions in mammals.
In higher eukaryotes, the majority of insulator elements bind to the highly conserved zinc-finger protein CTCF which has been shown to mediate diverse regulatory functions including promoter activation and repression, gene silencing, insulation, and imprinting [1], [2].
It is likely that several domains for protein-protein interactions differentially mediate diverse GluRδ2 functions [19], [21], [42], [43] and multiple PDZ proteins interacting with the carboxyl terminal of GluRδ2, such as Delphilin, PSD-93, PTPMEG, nPIST and S-SCAM [22], [28], [44] [46], may positively or negatively regulate LTD by mediating different downstream signaling.
This signaling cascade is known to mediate diverse biological functions, including cell proliferation, survival, fate determination, and differentiation.
34– 41 The ability of the CaSR to interact with unique members of family C GPCRs could further render its ability to mediate diverse neuronal functions in a cell context-dependent manner.
