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Taken together, perceived message clarity and perceived CSR are expected to mediate different responses to concrete CSR messages among individuals with high vs. low uncertainty avoidance (Kim 2006; Kim et al. 2010; Lin et al. 2011; Stanaland et al. 2011; Tian et al. 2011; Yalch & Elmore-Yalch 1984).
Nevertheless, it is believed that different stress signals can lead to different, as well as independent pathways for p53 activation, which in turn can mediate different responses [ 31].
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Here, we show that different isoforms of OPN4 mediate different behavioral responses to light.
Here, we show that OPN4 isoforms mediate different behavioral responses to light, such that OPN4S mediates the PLR; OPN4L negative masking and both isoforms mediate phase shifting of locomotor behavior and sleep induction in response to light.
It has been proposed [ 2] that different TRGC genes, each possessing unique connecting regions [ 22], could mediate different cellular responses after the T cell receptor has engaged the antigen.
What are the signals mediating these different responses?
The Hif-2 α subunit shows properties similar to Hif-1 α, but is mainly expressed in the stromal macrophages, and may mediate a different response to hypoxia (Talks et al, 2000).
Hence, it has been reported that depending on the integrin clustering status AEA-mediates different endothelial responses (Waldeck-Weiermair et al., 2008) while AEA failed to trigger cellular Ca2+ responses in the presence of extracellular Ca2+ in the EA.hy926 cells although this cell type expresses large amount of TRPV1 (Fig. 2A).
LPS priming alone caused differential expression of 40 genes and mediated significantly different response to a subsequent E. coli challenge of 226 genes.
Furthermore, this is the only example in visual biology that naturally occurring opsin isoforms mediate different physiological and behavioral responses to light.
Upon activation, naïve CD4+ T cells differentiate into different subsets of effector T cells, including Th1, Th2, Th17, and T follicular (Tfh) cells, which secrete distinct cytokines and mediate different aspects of immune responses [ 45].
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