Sentence examples for mediate different effects from inspiring English sources

The diverse actions of IL-1 are mediated by receptors produced by a signal IL-1R1 gene; but the expression of IL-1R1 in different cell types are known to mediate different effects via distinct signal transduction pathways.

An important finding of the present study is the observation that distinct TLRs mediate different effects on epithelial homeostasis.

Although a few studies have suggested that different integrins mediate different effects on Rho GTPase activity [38], [39], it is not clear how signaling downstream of one matrix-integrin contact differs from that mediated by another interaction or how multiple simultaneous signals are integrated.

It is also possible that different expression levels of FABP7 mediate different effects during disease progression.

In particular, our analysis revealed that CpG coverage and methylation status at the 12th position of the CTCF binding motifs have a marked effect on the colocalization of cohesin, which in turn implies that the variations in the CTCF binding sequence mediate different effects on chromatin interactions.

Since OPN can be produced by many cell types in a tumour microenvironment, including tumour cells themselves, activated immune cells, remodelling vasculature, and bone cells, in the case of tumours growing in bone; it may be that OPN from different sources mediate different effects.

As TGF- β1-induced apoptosis and EMT mediated different effects during tumor progression and embryonic development, they may be mutually exclusive processes.

Another explanation for this finding could also be that the dispersed oil mediated different effects in different organs, e.g. strong induction of cyp1a1 transcription via AHR activation by aromatic hydrocarbons in liver, and effects via other mechanisms on ahrr transcription in other tissues.

Since these two ER subtypes are thought to mediate different biological effects, there is intense interest in designing subtype-selective ER ligands.

As a result, there are sensitive periods during development when drugs or conditions that activate GABAA receptors mediate different transcriptional effects in males and females.

All these receptors belong to the large family of G protein-coupled receptors (GPCRs) and mediate different pharmacological effects of the hormones.