Genetic and biochemical studies indicate that distinct signal transduction pathways mediate different aspects of high salt stress, which ultimately lead to reprogramming of metabolism, physiology and morphology [5].
This led to the assumption that the different regions mediate different aspects of self-reference.
This double dissociation suggests that different hippocampal sub-regions may mediate different aspects of hippocampal function [5].
Once activated, p53 induces up-regulation of p21 and Bax, which mediate different aspects of p53 function on proliferation arrest and apoptosis [ 38, 39].
Moreover, a range of synaptotagmin-family transcripts, which mediate different aspects of calcium-dependent vesicle release, are selectively regulated in AGRP neurons by food deprivation.
Interestingly, the integrin expression profile in EPCs is variable throughout endothelial differentiation, further suggesting that integrin-ECM interactions can mediate different aspects of the endothelial differentiation process.
For higher ΔT, we found neuropeptide but not glutamate involvement in mediating different aspects of the thermal avoidance behavior.
Indeed, a range of subcellular structures mediating different aspects of mechanotransduction has been identified including mechanosensitive ion-channels, 16 the plasma membrane, 18 the cytoskeleton, 26 the nucleus, 24 and cell-adhesion complexes.
The various strands of evidence pointing to the discriminatory action of the partially redundant CBP60g and SARD1 in mediating different aspects of the immune response were reinforced when surveying the microarray datasets.
For example, the different intracellular signaling pathways associated with STAT3, NFκB, SOCS3, Nrf2, cAMP, Olig2 are implicated in mediating different aspects or different degrees of reactive astrogliosis such as GFAP up regulation, cell hypertrophy, proliferation, and pro- or anti-inflammatory effects [ 226].
Previous functional imaging and lesion evidence suggests that the temporal pole and anterior fusiform participate in a cooperative network mediating different aspects of semantic processing (Ellis et al., 1989; Tranel et al., 1997; Papagno and Capitani, 1998; Grabowski et al., 2001; Thompson et al., 2004; von Kriegstein et al., 2005; Tranel, 2006; Mion et al., 2010).
