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We recently showed that amphiphilic random copolymers based on the hydrophilic p N- 2-hydroxypropyl -methacrylamide), p N- 2-hydroxypropyl -methacrylamideed hydrop N- 2-hydroxypropyl -methacrylamideare able to mediate delivery of domp N- 2-hydroxypropyl -methacrylamideivo.
This demonstrates the competence of the binding and translocation domains of PE to mediate delivery of the DTA and RTA catalytic domains into cells cytoplasm and, importantly, that NS3 cleavage mediated enhancement in the enzymatic activity of the two zymoxins (as was detected by in-vitro assays) is practically translated to enhancement in cytotoxic activity.
Exocytic and endocytic processes mediate delivery of newly formed AChR and retrieval of old AChR, respectively.
Our data suggest that endogenous TbARL6 is associated with small vesicles throughout the parasite body and we speculate that TbARL6 could mediate delivery of the BBSome components on these vesicles.
The type III secretion system (TTSS) utilizes a flagellum-like tube to translocalize effector proteins into eukaryotic host cells, whereas the type IV secretion system (TFSS) employs a pilus-based structure to mediate delivery of DNA or proteins into target cells.
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Gene therapy-mediated delivery of angiogenesis inhibitors may provide an alternative approach to treating refractory tumors such as neuroblastoma.
Interestingly, S. Typhi does not encode a homolog for the "B" subunit of the holotoxin, CdtA or CdtC, which mediates delivery of CdtB into target cells of the pathogens listed above [48].
The adapter protein p62 (SQSTmediatesates delivery of ubiquitinated cargo to autophagosomes.
From the TGN, multiple pathways to the endosomal system arise, mediating delivery of essential components to various endosomal intermediates.
The reduced folate carrier (RFC1) is an integral membrane protein and facilitative anion exchanger that mediates delivery of 5-methyltetrahydrofolate into mammalian cells.
The gene gun mediated delivery of a single gold microcarrier carrying the fEGFP expression plasmid results in the intense labeling of the whole dendritic tree as well as all dendritic spines of an individual pyramidal neuron.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com