Sentence examples for mediate deletion of from inspiring English sources

We tested the ability of FLP and Cre recombinases, expressed conditionally in P. falciparum, to mediate deletion of the human dihydrofolate reductase (hdhfr) drug resistance gene.

In certain mouse strains, endogenous superantigens encoded by incorporated Mtv genomes mediate deletion of cells expressing particular Vβ segments.

This locus is a known hotspot for IS 6110 insertions and has been shown to mediate deletions of segments of this region [ 42].

In our model, Cre recombinase expression is driven by the DAT promoter and mediates deletion of exon 5 of the pten gene approximately at embryonic day 15 [15].

The DNA was used in a semi-quantitative PCR assay in order to determine the efficiency of cre recombinase mediated deletion of Nbn exon 6 and thus the proportion of homozygous or heterozygous null mutant cells.

We hypothesized that the amelioration of in vivo and in vitro defects in keratinocytes from aging hpm and K5-β1 mice, respectively, could be due to the expansion of keratinocytes that escaped NMD or Cre-mediated deletion of the floxed allele and had elevated β1 integrin levels.

This induces overexpression of exogenous FoxN1 after Cre-mediated deletion of the roadblock STOPflox.

Thus, Cre-mediated deletion of exon 2 generates a truncated form of REST unable to bind to DNA.

In targeted tissues, Cre-mediated deletion of exon 4 introduces a reading frame shift to render the allele null.

These recently published studies have used the strategy of Cre-mediated deletion of the IKK2 to inhibit NF-κB signaling in myeloid cells.

A genomic PCR analysis verified that Cre-mediated deletion of the flΔneo allele had occurred in T-PDKL155E/− DPs (Supplementary Figure 4).