Sentence examples for mediate clearance of from inspiring English sources

We demonstrate that anti-CD19 CAR T cells produced in this manner do not express the endogenous TCR, exhibit potent effector functions in vitro, and mediate clearance of CD19+ tumors in an in vivo mouse model.

Indeed, a balance exists between proteasome function and autophagy or lysosomal-based degradation as complementary and compensatory mechanisms to mediate clearance of misfolded proteins [34], [35].

While functional effector memory T cells mediate clearance of tumor and infected cells in vivo, central memory T cells appear to play an indispensible role in the long-term control [1], [32].

More specifically, AGO1 and AGO7 mediate clearance of Turnip crinkle virus —with AGO1 targeting viral RNAs with compact structures and AGO7 and RDR6 less-structured RNAs [52]— while AGO1 mutants are impaired in resistance to Cucumber mosaic virus (CMV) [63], and AGO2 and AGO5 have the ability to bind CMV-derived sRNAs [64].

Th1 and Th2 cells exert their immune functions through secretion of distinct patterns of cytokines: Th1 cells mediate clearance of intracellular pathogens by producing IFN-γ and TNF-α while Th2 cells are involved in elimination of parasitic organisms by secreting IL-4, IL-5, and IL-13 [4], [5], [5].

Based on our in situ data, supported by traditional biochemical data, we propose a pathway by which isoform specific conformational differences increase the level of cleavage at the hinge region of ApoE4, leading to a loss of ApoE function to mediate clearance of Aβ and thereby increase the risk of AD for carriers of the APOEε4 allele.

Surfactant protein D (SP-D) mediates clearance of microorganisms and modulates inflammation in response to cytotoxic stimulation.

A second question involves the cellular location of the mechanisms mediating clearance of Ca2+ from the cilium.

If LRP directly affects amyloidogenesis by mediating clearance of Aβ peptides, then one would have predicted that the above study would have produced mice with lowered amyloid burden.

It also mediates clearance of plasma lipoproteins and contributes to redistribution of lipids to cells [ 7].

APOE regulates transport of cholesterol and lipids throughout the body and mediates clearance of plasma lipoproteins [ 30].