Sentence examples for mediate cellular transformation from inspiring English sources
Stat3 has been defined as an oncogene in light of its ability to mediate cellular transformation and block apoptosis [ 9].
In studies performed in rodent fibroblasts, STAT3 activation has been demonstrated to be both required and sufficient to mediate cellular transformation.
This is of key interest as a previous study already had demonstrated that constitutively activated STAT3 can mediate cellular transformation (Bromberg et al, 1999).
Mutated Ras can mediate cellular transformation through a network of signal-transduction pathways independent of upstream RTK activation (Malumbres and Barbacid, 2003).
Abrogation of SOCS6-mediated YAP turnover is required for efficient Ras-mediated cellular transformation.
The Ras oncogene mediates cellular transformation without evidence of pStat3 in cultured cells.
This suggested that autocrine EGFR ligand secretion was an important component of Ras-mediated cellular transformation.
MUC1 function involves mediating cellular transformation in integrating the growth factor receptor and Wnt signalling pathways (Ren et al, 2002).
Nuclear PIM1 has been proposed to be more potent in mediating cellular transformation, at least in vitro, in solid cancer cell lines (Chen et al, 2009; Peltola et al, 2009).
Other research results have reported on the significance of the viral oncoprotein E6 from HR-HPVs in mediating cellular transformation, supporting tumorigenesis, interfering with epithelial organization, and activating telomerase.
Interestingly, a decrease in TDAG51 expression during Ras-mediated cellular transformation promoted the growth of cells under anchorage-independent conditions but did not affect the growth of attached cells.
