This critical involvement of DOCK8 in immune cell functions could in turn determine the role of septin 7 in the immune system, considering the fact that septins act as potential scaffolding platforms for interacting proteins, which mediate cellular functions.
Phosphorylated VEGFRs are considered to mediate cellular functions by activating various types of signaling pathways.
Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes.
This could signify that most complex variations mediate cellular functions that are important for strain fitness independent of the growth conditions.
It is becoming increasingly clear that lipid droplets mediate cellular functions other than fat storage and mobilization relevant for energy homeostasis.
It is worth noting that eight type IV pilus assembly proteins belonged to this group including pil C, D, G, I, M, N, O and P. Type IV pili have been implicated in the pathogenicity of gram negative bacteria, and mediate cellular functions such as twitching motility, host-cell adhesion and cell signaling [ 30].
Emerging evidence has demonstrated that β-arrestin1 mediates cellular function in some solid tumours.
Myosin II motor proteins are believed to be involved in mediating cellular functions by undergoing filament assembly in the cells.
OPN, a secreted phosphoprotein, exists both as an immobilized ECM molecule in mineralized tissues and as a cytokine that mediates cellular functions involved in inflammation and ECM remodelling [31].
Therefore, effector proteins such as AES and/or LRP6-ICD which are capable of modulating TCF/LEF-1 activity through long Groucho/TLE and/or β-catenin, have the potential to influence Wnt pathway mediated cellular functions such as proliferation/differentiation.
