Sentence examples for mediate cell survival from inspiring English sources
The system allows the investigation of downstream and parallel signaling networks, based on the ability of Pvr to activate Ras/Erk, Akt/TOR, and yet-uncharacterized signaling pathway/s, which redundantly mediate cell survival and contribute to proliferation.
It was therefore important to investigate whether binding of CTLA-4 to PI 3K leads to activation of PKB/AKT and its downstream targets such as GSK3 α/β and BAD to mediate cell survival.
Serum and glucocorticod kinase is an interesting target kinase of ERK5 [ 175]; it may mediate cell survival influences of ERK5 to cellular stress [ 176].
Therefore it is also not clear how selective (MVB) and non-selective (autophagy) lysosomal proteolysis pathways cooperate to mediate cell survival during nutrient limitation.
These factors may all mediate cell survival or death [ 3], and it appears that their patterns of expression tended towards activation of apoptotic mechanisms [ 1, 4].
Previous studies from our laboratories have demonstrated that a subset of tumor-derived p53 mutants mediate cell survival in breast cancer cells that expressed them.
Cell cycle analyses are shown in Supplementary Figure S2A and B. These results suggest that autophagy acts as a mediator of cell death during vorinostat initial exposure, but mediates cell survival following chronic exposure.
Among these, NF- κB has been reported to play a vital role in mediating cell survival and the upregulation of many cytokines and proinflammatory mediators essential to the host and ERK1/2 has been reported to mediate transcription of proteases and cytokines in response to an array of stimuli, including cigarette smokers [ 52].
Gutierrez-Uzquiza, A., Arechederra, M., Bragado, P., Aguirre-Ghiso, J. A. & Porras, A. p38alpha mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway.
However, with sustained cardiac stress, cellular processes mediating cell survival, metabolism, and the maintenance of normal cardiac architecture begin to fail.
The matrix metalloproteinase Mmp11 mediates cell survival in epithelial cells via activation of PKB/Akt [83].
