Tropomyosin has been shown to be important for regulating the actin mechanics in the cell cytoskeleton, and can mediate changes in cell morphology, adhesion and migration [ 27, 28].
The core proteins then recruit tissue-specific 'effectors' to specific cell edges to mediate polarised changes in cell morphology and behaviour.
TORC2, which includes Rictor, is implicated in the control of cell morphology mediated by regulation of the actin cytoskeleton [33].
We also demonstrated that ErbB2 is responsible for mediating LOXL2 effects on cell morphology and behavior, and present here an exciting new mechanism by which LOXL2 may regulate cellular behavior through production of ROS.
They mediate various biological processes including cell morphology, adhesion, motility, proliferation, differentiation, fusion, invasion, phagocytosis, exocytosis, receptor signaling, synapse formation, protein trafficking, and more [ 3- 9].
TORC2 may also regulate cell growth, but importantly also appears to regulate cell morphology by mediating actin cytoskeletal modifications in response to growth factors.
In the cytoplasm, actin forms a network of filaments that mediates macromolecular transport and maintains cell morphology.
Important functions have been identified for ParvB in integrin-mediated cell adhesion, regulation of cell morphology and cell motility, which are mediated through interactions with ILK by the CH2 domain.
Moreover, the aberration in intestinal epithelial cell morphology and actin filament organization mediated by TcdA may, at least, partially account for the severe intestinal mucosal disruption found in C. difficile-induced disease.
Moreover, TDCPP exposure did not result in obvious effects on the cell cycle, overall embryo size, or cell morphology during cleavage, suggesting that TDCPP mediates toxicity at the subcellular or genomic level during this stage of embryogenesis.
