Cilia and flagella power cell locomotion and mediate cell signaling in eukaryotes.
Alternatively, these agents may induce phenotypic changes in cells including nontransformed cells, increasing membrane ruffling, cell locomotion, and extracellular matrix-independent growth mediated by transforming-growth-factor [ 37].
DOI: http://dx.doi.org/10.7554/eLife.00744.002 Cilia and flagella are microtubule-based organelles that power the locomotion of many organisms, generate fluid flow over multiciliated surfaces, and mediate cell signaling (Liem et al., 2012).
These cells affect each other by releasing there specific signal substances, which in turn can activate via receptor mediated cell signaling their locomotion and proliferation attitude.
Weiss, P. Guiding principles of cell locomotion and cell aggregation.
Mitchison, T. J. & Cramer, L. P. Actin-based cell motility and cell locomotion.
Pelham, R. J. Jr. & Wang, Y. Cell locomotion and focal adhesions are regulated by substrate flexibility.
Pelham, R.J.J. & Wang, Y. Cell locomotion and focal adhesions are regulated by substrate flexibility.
Integrins are membrane receptors that mediate cell adhesion and mechanosensing.
Thus, metabolic control of T cell locomotion provides new opportunities to interfere with T cell invasion into specific tissue sites.
