Together these results place EGFR/MAPK and Stat activation as key in vivo mediators of Src-driven stem cell hyperproliferation in the Drosophila intestine.
For example, others found that WSX1 absence will induce hyperproliferation of T cells after infection with Trypanosoma cruzi [36], suggesting that the presence of WSX1 is needed to suppresses T cell hyperproliferation after the infection.
H. suis causes death of parietal cells, epithelial cell hyperproliferation and severe inflammation in mice and Mongolian gerbil models of human gastric disease.
Again, the inhibitors of Hh and Wnt signaling, but not Notch signaling inhibitors ( Figure 5B and Figure S5) blocked their anchorage-independent growth and cell hyperproliferation.
While we observed similar changes in basal cell hyperproliferation and defects in spinous markers of differentiation, we did not observe the granular changes reported in developing skin.
This is supposed to induce cell hyperproliferation [ 43].
Fgf10 overexpression in the stromal compartment of the murine prostate results in epithelial cell hyperproliferation [ 31].
Phospho-EGFR and EGFR expression were associated with tumour cell hyperproliferation.
Polyamine levels are significantly increased during the process of transformation in order to sustain cell hyperproliferation [ 1, 28].
The production of proinflammatory cytokines by synovial macrophages and fibroblasts is one reason for synovial cell hyperproliferation.
