Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death.
It can probably not only mediate cell death but also regulate cell growth.
So far, this approach has been limited mostly to the identification of genes that mediate cell death in response to a lethal agent, likely due to the ease with which this phenotype can be observed.
A novel family of immunoregulatory, carbohydrate-binding receptors, the Siglecs (sialic acid binding immunoglobulin-like lectins), has received particular attention in light of their capacity to mediate cell death, anti-proliferative effects and to regulate a variety of cellular activities.
It is apparent from these results, however, that bax is not required to mediate cell death in prostatic glandular epithelial cells following castration.
GAPDH can mediate cell death associated with oxidative stress [92].
Controversy exists as to the ability of caspase-10 to mediate cell death in response to FasL (CD95L or CD178).
Since we observed that ROS mediate cell death in murine hepatocytes, we next examined the activity of JNK by Western Blotting of the active form phospho-JNK.
Based on studies on cultured oligodendrocytes, AMPA and kainate receptors are located on oligodendrocytes and they mediate cell death [11], [12].
Caspase-10 activity was required for its ability to mediate cell death since the expression of a catalytically inactive caspase-10 (C401S) had no cytotoxic effect.
In contrast to the present study, activation of JNK1 (via oxidative stress) has previously been shown to mediate cell death via PARP-1 activation [21].
