Sentence examples for mediate cell cycle from inspiring English sources

We suggested that IR activates AMPK acutely in epithelial cancer cell cultures to transduce signals through a DNA damage response (DDR -mediated ataxia telengiectasia-mutateDDR -mediatedp53-p21cip1 ataxiaand mediate cell cycle arrest and radiosensitisation (Sanli et al, 2010).

Khmelinskii, A., Roostalu, J., Roque, H., Antony, C. & Schiebel, E. Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation.

Identifying the genes and pathways that mediate cell cycle exit downstream of RA will be critical for our understanding of how to target tumor differentiation.

Unlike deletion of apoptosis genes, genes that mediate cell cycle exit by differentiation are present in myelodysplastic syndrome (MDS) and AML cells but are epigenetically repressed: MDS/AML cells express high levels of key lineage-specifying transcription factors.

Exonuclease 1 (EXO1) is an important nucleases involved in mismatch repair system that contributes to maintain genomic stability, to modulate DNA recombination, and to mediate cell cycle arrest.

Regarding the adult liver-enriched miRNAs, similar to let-7, miR-23b is capable of inhibiting cell proliferation [44], and may mediate cell cycle arrest in mature hepatocytes.

Wee1 is a critical component of the G2/M cell cycle checkpoint machinery and mediates cell cycle arrest by phosphorylation of CDC2.

These results provide evidence suggesting that NFκB mediates cell cycle progression and demonstrates a mechanism linking increased NFκB activity with GBM cell growth and cell cycle disregulation.

We hypothesized that double-stranded DNA with high affinity for E2F may be introduced in vivo as a decoy to bind E2F and block the activation of genes mediating cell cycle progression and intimal hyperplasia after vascular injury.

p53 mediates cell cycle arrest or apoptosis in response to DNA damage.

The IMPDH inhibitor MPA has been shown to activate and stabilize p53, which in turn mediates cell cycle arrest and apoptosis in response to guanine nucleotide depletion [30] [32].