Furthermore, it may reverse angiotensin-2-mediated mesangial cell contraction [ 14], thereby increasing glomerular capillary surface area [ 48].
The reorganisation and redistribution of the cytoskeleton regulated by profilin-1 mediates endothelial cell contraction, which results in vascular hyperpermeability.
They also mediate vascular endothelial cell contraction and strengthen phagocytic cells [ 3].
Hepatic stellate cell contraction is mediated through both Ca2+-dependent and independent pathways [ 82].
Lysophosphatidic acid (LPA; 1- or 2-acyl sn-glycero-3-phosphate), the simplest glycerophospholipid, mediates a broad range of cellular responses including smooth muscle cell contraction, platelet aggregation, neurite retraction/cell rounding, regulation of cell proliferation, protection from apoptosis, modulation of chemotaxis and transcellular migration [ 1- 3].
In vitro, Ang-2 simultaneously mediates disassembly of cell cell and cell matrix contacts, and causes active endothelial cell contraction in a Rho kinase-dependent fashion, followed by massive plasma leakage and loss of vasomotor tone [ 3, 10].
In the airway, Src mediates serotonin-evoked peak Ca2+ responses by affecting phosphoinositide levels to alter cell contraction [ 15].
Our results show BIM plays a key role in T cell contraction even when cytokines are abundant, indicating that FAS- and BIM-mediated T cell apoptosis are not mutually exclusive pathways as recently reinforced in the literature [ 7].
Furthermore, studies on cultured human umbilical vein or coronary artery endothelial cells revealed a novel effect of Lp(a) that was mediated by its apo(a) component: impairment of the barrier function of endothelial cells through cell contraction occurring as a consequence of a rearrangement of the actin cytoskeleton [ 44].
Integrins are membrane receptors that mediate cell adhesion and mechanosensing.
