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However, the putative PC ligands that mediate brain adhesion remain to be identified.
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Adhesion molecules mediate rolling and adhesion of homing cells to the blood vessel wall [ 27].
Ddr homologs can mediate weak adhesion to collagen and increase integrin-mediated adhesion to collagen-based extracellular matrices34,39.
Ahn, B. J. et al. Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats.
Integrins are membrane receptors that mediate cell adhesion and mechanosensing.
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.
Cell surface-proteins like the cell adhesion molecules (CAMs) e.g. cadherins, immunoglobulin-like CAMs (Ig-CAMs), or integrins mediate cell adhesion by homophilic or receptor-ligand interactions14.
Together, the CAMs mediate the adhesion response to external stimuli, and inside-out signaling transduction.
These glycoproteins mediate platelet adhesion and adherence.
Integrins are the receptors that mediate cell adhesion to ECM.
However, cadherins do not just passively mediate cell adhesion.
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