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These RASSLs can be used to activate Gs signaling in any tissue, but would be particularly useful for analyzing downstream events that mediate body weight regulation in mice.
Therefore, it is likely that leptin may act upon the peripheral lipogenic program in the face of overnutrition to mediate body's metabolic adaptation responses.
Eyes mediate body bending during visual phototaxis.
DOI: http://dx.doi.org/10.7554/eLife.02730.038 To directly investigate if the eyes are able to mediate body bending we performed selective eye illumination experiments on larvae held between a slide and a coverslip.
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If Mr. Gore and Mr. Bush are unable to agree on what they would consider decisive, Professor Greenstein said, it might be wise to name some mediator or mediating body.
Future experiments should utilize genetic tools to delete leptin receptor expression in specific populations of neurons as was done by Bradford Lowell, Joel Elmquist, and colleagues to delineate the crucial population of leptin receptor expressing neurons responsible for mediating body weight homeostasis [24], [25], [41], [42].
Chromatophores are the primary agents contributing to body coloration and mediating body coloration changes in response to light.
IGF-1R mediates body growth through the effects of IGF-1 on cell proliferation, differentiation, and apoptosis.
The role of insulin/Igf signaling in mediating body response to nutrients, and the fact that IIS is reduced by calorie restriction protocols, provided full rationale to these observations, that brought to the notion that aging may represent, rather than the uncontrolled catastrophe of the body, the product of a genetically coded programme.
This gene is actually duplicated in the A. gambiae genome as AgToll1 and AgToll1B, both of which are closely related to AgToll5A and AgToll5B, as well as to D. melanogaster Toll, DmToll1, encoding the receptor mediating body axis formation, and to DmToll5 [ 32].
Given the fact that integumental colour in invertebrates and its role in mediating body temperature have been a focus for population and ecological genetics for almost a century, it is not surprising that a large amount of data exist for these trait systems.
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