Integrins α3, α4 and α7 mediate binding to laminins, while α2 integrin binds to collagen, and integrin αVβ8 is an RGD receptor (reviewed in [ 32]).
While the heterodimers α2 β1 and α6 β1 mediate binding to laminin, α4 β1 and α5 β1 predominantly bind to fibronectin [ 47].
IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins.
Structural analysis of the binding pocket identifies important intermolecular contacts that mediate binding.
These residues are predicted to mediate binding to proteins bearing a region called a PDZ domain.
HA is knownto mediate binding of viruses to target cells via terminal sialic acid residues in glycoconjugates.
Moreover, RCL appears to mediate binding to a cell surface receptor that promotes cell adhesion to type I collagen and fibronectin [12, 13].
That structure has now been exploited for elucidation of interface pharmacophores that mediate binding of CST to its target, with consequent secretory inhibition.
Both structures serve to mediate binding to nuclear transport proteins.
Other regions mediate binding, allowing proper positioning within the cell or conferring substrate specificity.
These regions were originally identified because they mediate binding to F-actin in vitro.
