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Nuclei within this circuit are known to mediate behavioral responses induced by social defeat [8], [21], [22], so we examined indirect markers of brain activity in these nuclei following social interaction testing.
Recent research has led to the hypothesis that the transition to alcohol dependence involves the dysregulation not only of neural circuits involved in reward but also of circuits that mediate behavioral responses to stressors.
Moreover, there is evidence that norepinephrine and CRF systems in the brain not only interact closely to mediate behavioral responses to stress, but also play an important role in negative affective states and relapse vulnerability during alcohol/drug abstinence (Dunn and Swiergiel 2008; Smith and Aston-Jones 2008).
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Findings from this preliminary study indicated that male veterans with TBI demonstrated the strongest association between OFC connectivity and measures of aggression, suggesting these circuits may mediate behavioral response such as aggression.
Gr63a and Gr21a and their orthologs are also responsible for mediating behavioral responses to carbon dioxide in mosquitoes, and inhibition of this receptor may prevent host seeking in mosquitoes (Turner and Ray, 2009; Turner et al., 2011).
It has been shown that neurabin and spinophilin play different roles in mediating behavioral responses to cocaine administration [20].
Studies in male hamsters have identified the BNST and several nuclei of the amygdala as important brain regions mediating behavioral responses to social defeat [63], [64], [65].
Several studies have suggested that the BNST mediates behavioral responses to acute and chronic aversive stimuli [ 5, 14].
However, a systematic analysis of the roles of OBPs in mediating behavioral responses to odorants has not yet been performed.
Alternatively, preservation of D1R mediated behavioral responses in Pdcl cKO mice may also indicate that signaling pathways other than cAMP initiated by D1 receptors (Nishi et al., 2011) play compensatory role.
DOI: http://dx.doi.org/10.7554/eLife.04878.008 If AF7-projecting RGCs are mediating behavioral responses to virtual prey, we reasoned that they should also respond to natural prey, such as paramecia.
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