Sentence examples for mediate association with from inspiring English sources
The resulting fusion protein has no DNA binding motifs but possesses protein-protein interaction domains that are believed to mediate association with chromatin remodeling complexes.
The hGBPs are isoprenylated at their C-terminus via the CAAX domain, and the addition of this hydrophobic tag is thought to mediate association with membranous structures [21], [26], [36].
Thus fly APC2's Arm rpts can mediate association with Axin's middle region.
Our hypothesis predicted deleting either R2 or B should stabilize APC2 Axin interaction, by enabling APC2's Arm rpts to also productively mediate association with Axin.
The p.L95F mutation is located in the conserved BTB domain of KLHL9, which mediates interaction with Cul3, while the Kelch repeats mediate association with substrates.
These results imply that the NTD contributes to complex stability and that there are multiple regions on the AMPAR that mediate association with TARP auxiliary subunits.
Transmembrane integrin molecules on the cell surface attach to the extracellular matrix (ECM), and the integrin-adhesion complexes mediate associations with the actin cytoskeleton.
The stability of E-cadherin contacts is regulated by the cytoplasmic domain of E-cadherin, which organizes the recruitment of multiprotein complexes that make up the adherens junctions (AJs) to mediate associations with the cellular cytoskeleton (Jamora and Fuchs 2002; Hartsock and Nelson 2008).
Recent data indicate that efficient nuclear import can involve the microtubule (MT)/dynein network, such that nuclear delivery of exogenous cargo could be enhanced by attachment to peptide modules mediating association with dynein components, but this has not been investigated.
These data suggest that TDP-43 can bind to TIA-1 at higher concentrations of TDP-43, such as with over-expression, but that binding to TIA-1 is not the predominant mechanism mediating association with SGs under basal levels of TDP-43 expression.
Alternative splice variants of TAF4 lack parts of the TAF homology domain, which mediates association with a variety of transcriptional factors.
