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Our results demonstrate that these BMPs are coexpressed in a number of tissues that are known to be the source of inductive signals, including the zone of polarizing activity and apical ectodermal ridge of the developing limb and the notochord, raising the possibility that BMP 2/7 heterodimers may mediate aspects of these tissue interactions.
It is tempting to speculate that this intersection includes genes that mediate aspects of KD/SBMA that are unique to polyQ expansion of AR.
Trophoblast cells release exosomes that mediate aspects of cell-to-cell communication.
As an SH2-containing adapter protein GRB7 can interact with phosphorylated HER2 and mediate aspects of cell migration through binding with focal adhesion kinase [ 48, 49].
Using our zebrafish model, we have recently shown that the cftr gene responsible for CF and arsenic each separately mediate aspects of innate immunity [ 15, 18– 20].
Previously, it had been found that the mammalian sirtuin SIRT1 is required to mediate aspects of the CR response in mice [ 14, 15].
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Overall, these studies demonstrate, through the use of novel transgenic mice, that IL1R1 on neurons and astrocytes differentially mediates aspects of sleep under physiological conditions and in response to central IL-1 administration.
Since both histofluorescence and biochemical studies indicated that CNS norepinephrine levels were decreased in lesioned as compared to control animals, the findings are interpreted as showing that noradrenergic neurons originating in the locus coeruleus play an important role in mediating aspects of the relationship between fighting behavior and blood pressure response.
Some of these co-expressed genes are likely to be involved in mediating aspects of petaloidy.
(4) is1 is a potent pro-inflammatory cytokine, which mediates aspects of the "sickness behavior", a syndrome sharing similarities with major depression [33].
Transgenic mice have demonstrated the importance of 11β-HSD1 in mediating aspects of the metabolic syndrome, as well as HPA axis control.
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