The proton-coupled folate transporter (PCFT/SLC46A1), which is representative of various proton-coupled low pH carriers, that mediate intestinal absorption of various essential nutrients [20], [21], [22], was further examined.
These results thus suggest that both dZip1 and dZip2 mediate the absorption of dietary zinc from lumen into the cytosol of the enterocyte.
Accordingly, specific transporters have evolved to mediate intestinal absorption of dietary folates, renal tubular secretion and reabsorption of folates, and transport of circulating reduced folates into systemic tissues [ 3].
Chicken VLDLR, also named oocyte vitellogenesis receptor (OVR) or vitellogenin receptor (VTGR), mediates the absorption of yolk protein precursors from plasma very low density lipoprotein and vitellogenin.
SGLT1 is predominantly expressed in the small intestine, mediating the absorption of glucose (e.g. D-glucose), but also occurs in the brain, heart and in the late proximal straight tubule of the kidney.
Vitamin C mediates the absorption of iron, a prooxidant that can be stored by the organism, and that has been associated with a major risk of cardiovascular diseases and formation of hydroxyl radicals through the reactions of Haber Weiss and Fenton.
Equally important, the deficiencies only rarely arose from disruption of IF-mediated absorption, such as pernicious anemia (8, 10, 14).
Thus, we speculated that the deglycosylation of ADS-I to the metabolites (M1 and M2) might mediate the intestinal absorption of ADS-1 for increased oral bioavailability.
These differences may be due to the relative contribution of on- and off-target effects to these organ systems, or to the importance of modality to these organ systems; gastrointestinal side effects, for example, may be more often mediated by the absorption of a drug than its effect on its target.
