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In humans, resolvins, lipoxins and prostaglandins promote or resolve inflammation [1], [2], [3] while in plants, oxylipins mediate a wider range of physiological activities [4], [5], [6].
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Heparin binding (HB) proteins mediate a wide range of important cellular processes, which makes this class of proteins biopharmaceutically important.
Reactive oxygen species (ROS) are chemically reactive molecules that can mediate a wide variety of biological processes.
G-protein coupled receptors (GPCRs) are a large family of membrane-bound receptors that mediate a wide range of physiologic responses to hormones, neurotransmitters and dietary lipids, which represent an important class of drug targets.
Naturally occurring knottins are found in a wide range of species including plants, animals and fungi, and mediate a wide range of functions including protease inhibition, ion channel blockade, and antimicrobial activity (Zhu et al., 2003; Gracy et al., 2008; Aboye et al., 2015; Tam et al., 2015).
Ferredoxins are iron-sulfur proteins that mediate a wide range of electron transfer reactions.
These signals mediate a wide variety of physiological responses, including heart rate, chemotaxis, cell proliferation, neurotransmission, and hormonal responses.
STAT proteins mediate a wide range of biological processes, including cell growth, differentiation, apoptosis, inflammation and immune response [15].
Wnt proteins constitute a family of highly conserved growth factors [1] that mediate a wide range of biological processes, including proliferation, migration, and differentiation.
Mammalian thrombospondins are a group of matricellular proteins of complex spatial structure, which mediate a wide range of intercellular activities, and participate in cell-matrix interactions.
To date, 129 p53-responsive genes have been identified that encode proteins, which mediate a wide variety of cellular stress responses [3].
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