Of the three mammalian isoforms A-RAF is special in that one of its two lipid binding domains mediates a unique pattern of membrane localization.
The product of the O-6-methylguanine-DNA methyl-transferase (MGMT) gene mediates a unique DNA repair pathway by removing methyl/alkyl groups from O-6-alkyl-guanine (G) and thus protecellsells from mutagenic and cytotoxic effects of alkylating agents [39].
These preferences are possibly mediated by a unique for this aminopeptidase, extended peptide binding site.
Macroautophagy is mediated by a unique organelle the autophagosome.
The synthesis of angiotensin- 1-7) is mediangiotensin- 1-7 RAS pathway isvolving ACE2 [ 47, 48].
Furthermore we uncovered a lipid binding property which is mediated by a unique extended basic loop between blades 6 and 7 of the propeller.
When taken together, our results suggest that, in immobilized muscles, the isometric-contraction-induced increase in protein synthesis is mediated through a unique rapamycin-sensitive/mTOR-dependent mechanism that does not involve changes in eIF4F formation or eEF2 activity.
For example, the asymmetrical expression of neurotransmitter receptors in A1 and MG implies that excitatory, inhibitory, and modulatory inputs to each region are mediated by a unique blend of receptor types that variably influence activity [ 26, 18, 22].
In the limited sample, the correlation between IQ and the coincidence timing measures appeared to be mediated largely by a unique environmental factor, with only a small loading of SD on the genetic factor influencing IQ.
This integrated genome-wide data on IL-4 and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
