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We propose that these stable motif architectures have been conserved intact from a deep ancestor, in part because they mediate a special mode of regulation that cannot be supplied by the other, unstable motif instances.
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In the heart, rectum, and bladder, pain appears to be due to a summation of impulses in sensory nerve fibres and may not be mediated by a special group of fibres reserved for reporting noxious events.
Macroautophagy (hereafter referred to as autophagy) is a major intracellular degradation system that, in eukaryotes, is mediated by a special organelle, the autophagosome., Upon autophagy induction, small pieces of the cytoplasm are enclosed by phagophores, which mature into autophagosomes.
Classical studies by Spemann and Mangold (Spemann and Mangold, 1924; translated by Hamburger, 2001) showed that the emergence of the nervous system requires an inductive event mediated by a special group of cells, called the 'organizer', on a layer of overlying neuroectodermal cells (Spemann and Mangold, 1924; De Robertis et al., 2000; De Robertis, 2009).
Different microorganisms, either gram-positive or gram-negative, can exchange electrons with electrodes and this is accomplished by different mechanisms: reduction of self-produced soluble shuttles; short-range electron transfer through membrane-bound redox-active proteins (i.e., c-type cytochrome); long-range electron transfer mediated by a special class of conductive pili, the nanowires [ 12].
Calvin Coolidge recalled him to public life in 1927 as a special commissioner to Nicaragua to mediate a civil dispute, which he successfully reconciled.
Gen. Anthony C. Zinni, the American special envoy who tried unsuccessfully to mediate a cease-fire, asked for permission to see Mr. Arafat today.
Subsequent UN efforts to mediate a truce in Darayya failed, and on Friday the UN's special envoy for Syria, Staffan de Mistura, said the UN had not been consulted on the agreement.
Try to mediate a resolution.
Administration officials said the United States pressed for the resolution on the eve of the departure of Gen. Anthony C. Zinni, Mr. Bush's special envoy for the Middle East, to resume his efforts to mediate an end to the violence.
One moment he must mediate an argument between rival sheiks.
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