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In other cell types, persistent hypoxia can result in cell death [20] or mediate a shift in mediator release and disturb cell functions [21], [22].
However, due to their high plasticity, peripheral monocytes in general are comprehensively suited to either develop to inflammation triggering cells or to mediate a shift to resolution.
The interplay between α5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior.
This study showed that the interplay between α5-integrin and sFn can contribute significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior.
These interactions mediate a shift of electron density at the carbonyl oxygen at the TS.
Based on our previous studies [ 13, 16], we predicted that phospho-Ser294-PRs (that is, that are primarily deSUMOylated) mediate a shift in gene regulation that profoundly affects cancer cell phenotypes.
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We suggest that insulin resistance mediates a shift from muscle dependent to brain dependent strategies of making a livelihood.
Together, these results suggest that Atf4 mediates a shift from a metabolism based on oxidative phosphorylation to one more heavily reliant on glycolysis, reminiscent of aerobic glycolysis or the Warburg effect observed in cancer and other proliferative cells.
LCA-induced hepatotoxicity was also diminished by pharmacologic activation of CAR, mediating a shift in BA biosynthesis toward the formation of less toxic BAs, as well as a decrease in hepatic bile acid concentrations.
A shift in the balance between cell signaling mechanisms could mediate a modal shift from vigilant rest to active task performance.
The increase in lactate observed through in vivo studies in flies subjected to ER stress, however, suggests that in a more physiological setting, the gene expression changes shown here do mediate a metabolic shift toward aerobic glycolysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com