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However, extracellular heat shock proteins have recently been shown to mediate a range of powerful effects in inflammatory cells, neuronal cells and immune cells.
Those factors can both activate further platelets and mediate a range of responses in other cells.
IFNs are a family of related cytokines that mediate a range of diverse functions including immunomodulatory and antiproliferative activities.
This inhibition is likely to mediate a range of downstream effects, including anti-inflammatory and anticancerous actions.
T helper 1 responses depend on IFN- γ to mediate a range of biological effects that facilitate anticancer immunity.
The formation of focal adhesions by various integrin types modulates different downstream signalling pathways that mediate a range of cell responses and functions.
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NF-κB mediates a range of biological processes in cancer cells by transcriptionally activating numerous target genes [ 41, 42].
Recent evidence suggested that FPR2, a G protein-coupled receptor (GPCR), mediates a range of inflammatory responses to A β42 in AD.
In lower eukaryotes, such as worms and flies, a hybrid PDGF (platelet-derived growth factor) and VEGF system of ligands and receptors mediates a range of biological responses.
They have since been implicated in mediating a range of membrane fusion events in all cell types, be it secretion, endocytosis or early-to-late endosome transport.
In fact, ERK1/2 is regarded as the most important member of the MAPK family capable of mediating a range of cellular responses, including motility, inflammation, and cell survival as well as cell death (Sawe et al., 2008).
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