Sentence examples for mediate a profound from inspiring English sources

The critical gene, well known for its role in suppressing tumors, seems to mediate a profound balance between life and death.

Third, mimicking the endothelial injury (presumed to occur in sepsis) by exposing the subendothelial matrix led to platelet adhesion that mediated a profound increase in subsequent adherence of activated neutrophils even in the presence of higher shear forces.

Subsequently, Utx mediates a more profound H3K27me3 removal and transcriptional activation of these homeobox genes in female cells.

The analogue (IRF1) of IRF7 has been implicated in the IFN gamma mediated apoptosis with a profound effect on the chemo-sensitivity of tumor cells [ 59, 60].

It has been proposed that adaptation to hypoxia is critical in emergence of the malignant phenotype because the combination of adaptations with upregulation of glycolytic metabolism and resistance to acid-mediated toxicity confers a profound proliferative advantage [ 9].

It has been proposed that adaptation to hypoxia is critical in emergence of the malignant phenotype because the combination of adaptations with upregulation of glycolytic metabolism and resistance to acid-mediated toxicity confers a profound proliferative advantage (need refs)).

The rearrangements detailed here demonstrate the plasticity of the B. mallei genome and suggest that IS mediated deletions may have a profound effect on the relative virulence of B. mallei strains.

These results suggest that nuclear FGFR1 and FGF2 may have a profound effect on PSC invasion, which in turn mediates cancer cell invasion.

Once ligated, RAGE mediates post-receptor signaling including activation of nuclear factor-κB (NF-κB), leading to a profound inflammatory response [27], [28].

But she has a profound new understanding of the way in which the vagina, in its hitherto underpublicised connection with the brain, "mediates consciousness".

A profound stillness descends.