Sentence examples for mediate a pleiotropy from inspiring English sources

ITAM-bearing FcγRs mediate a pleiotropy of functions in various cell types.

The association of C14H8orf34 with epinephrine production may also support a pleiotropy claim.

It is to our knowledge the largest pathway resource, with metabolic and signaling pathways from a pleiotropy of organisms.

Try to mediate a resolution.

TNF mediates a considerable degree of pleiotropy (13) through activation of different receptors; TNF receptor (TNFR -1 and TNFR -1(14, 15).

We have two reasons to believe that changes in the size of the oxyanion pocket surrounding the active site (Ser-70) mediate the observed pleiotropy.

A second genetic process that may help to explain an enrichment of positive selection on polygenic disease genes is balancing selection mediated by antagonistic pleiotropy, or other processes including overdominance or frequency-dependent selection.

This occurs over an individual's lifespan for plastic resource allocation traits (e.g. [ 87]) and over evolutionary time for those mediated by antagonistic pleiotropy or other genetic mechanisms".

Another possibility would be a negative pleiotropy: alleles increasing cold tolerance could also exhibit a lesser heat tolerance.

The results presented here are consistent with a partial pleiotropy between major depression and SA.

Small et al. (2014) found an unexpected pleiotropy between ROS production and immune cell differentiation mediated by Notch signaling in Drosophila.